Age-related Changes in Bone Architecture Vary among Inbred Strains of Mice
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چکیده
INTRODUCTION: There is strong evidence for genetic contributions to bone mass and architecture in mice and humans. Inbred mouse strains have recently been established as a valuable tool for studying the genetic regulation of skeletal phenotypes. We previously reported sex-related differences in age-related bone loss in C57Bl/6J mice [1] and mouse strain-related differences in the skeletal response to OVX [2]. However, there are few data showing age-related changes in bone architecture in different mouse strains. A better understanding of age-related changes in trabecular and cortical bone will enhance interpretation of murine studies with therapeutic and/or genetic interventions. In addition, characterizing the effect of age on skeletal morphology in different mouse strains may improve understanding of the genetic mechanisms underlying skeletal fragility in humans. Therefore, the objective of the current study was to assess age-related changes in trabecular and cortical bone in different inbred mouse strains.
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